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Trouvez le extension de fichier in question under this key in le registre:
HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\FileExts
Deleting the sub-key with the same name as the extension you want to un-associate will delete the default program association. In older Windows versions, you'll have to kill and restart explorer.exe for this to take effect (the change is instant as of Windows 10 64-bit).
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In most cases, you will also need to remove the same sub key from HKEY_CLASSES_ROOT aussi.