They talked him into doing things on his laptop
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Please disconnect this PC from the internet right now.
- If your uncle has used the PC for intenet banking then his bank account details may already be compromised.
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Let his bank know what has happened immediately.
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They will be able to advise him how to change his internet banking details over the phone.
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The talktalk scammers have already conned some individuals out of thousands of pounds.
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Change all his passwords (email, websites, etc)
- Do this from another computer you know is clean.
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Then get professional advice on how to fix this.
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You don't know exactly what trojans or whatever nasties have been left behind on this PC.
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Getting the password back is only the first step of a cleanup and the safest thing to do is to reinstall Windows.
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A professional IT support person should be able to get any personal files saved first (in a safe way) before Windows is reinstalled.
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But I really want to clean up this mess myself!
If you feel you have the technical skills to fix this then:
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See What can I do if I forgot my Windows password? to get back access to the machine.
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See How can I remove malicious spyware, malware, adware, viruses, trojans or rootkits from my PC? for cleanup instructions.
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As per comment by JamesRyan consider giving your uncle user access rights only (standard user account). If you are willing to support him in the future keep the Admin rights to yourself. That will at least limit the damages if it happens again.