thumbs.db is where the thumbnail images for files are stored. They will only be visible si vous avez your folder options set to display hidden and system files. They are not viral.
If you delete a thumbs.db file, the next time you open that folder, Windows will have to re-determine the thumbnail for each file.
Also, in Options des dossiers, selecting "Do not cache thumbnails" will prevent the thumbs.db files from being created.
Cependant, these files help the computer navigate through your directories more quickly, so unless you have a specific reason for not needing or wanting them, just leave them alone.