Vous pouvez changez le par défaut location on a per website/application basis by editing le Configuration section of le Web.config file.
<system.web>
<compilation tempDirectory="D:\MyTempFiles" />
</system.web>
The application will re-compile et le files will be stored at this nouveau location, après qui you can safely supprimez le old folders.
Note that le folder names will stay le same;
e.g. si le old location was:
C:\Windows\Microsoft.NET\Framework64\v4.0.30319\Temporary ASP.NET Files\root\9878g103\e67805p7
then le nouveau one will be:
D:\MyTempFiles\root\9878g103\e67805p7